THE PKRRATING DIARIES

The activated enzyme then phosphorylates its main substrate, the translational initiation aspect eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to a conserved spouse and children of 4 protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to diverse stimuli12, triggering the built-in strai